Reducing Lactobacillus levels in the Intestine may lead to Obesity and Type-2 Diabetes Treatment

Hello Readers,

I recently read about a research which was carried out by a team of researches in Penn State, now according to this research a drug that targets specific bacteria's in the intestine may create a chain of reaction which may help us treating obesity and diabetes.

This Research was performed on Mice, which were fed with a high fat diet and were provided with a drug called Tempol at the same time ( Tempol or 4-Hydroxy-TEMPO is an anti-oxidant that may help people against radiations), These Mice were significantly less obese than the mice who didn't receive Tempol, according to Andrew Patterson, assistant professor of molecular toxicology,Penn State.

So according to the researchers, Tempol-----------------reduces some members of bacteria (a genus of Lactobacillus) in the guts of mice---------------- and reduced level of Lactobacillus --------------- further leads to------------ An increase in the level of Bile Acid (tauro-beta-muricholic acid)----------------This, inhibits FXR( farnesoid X receptor)  Which is known to regulate the metabolism of bile acids, fats, and glucose in the body.

The researchers, also said that in addition to less weight gain, the tempol receiving mice had lower glucose and insulin levels in-spite of being in a high fat diet.

To further test the role of FXR in obesity, the researchers placed mice that were genetically modified so that they lack FXR on the same high-fat diet. This group was resistant to the effects of tempol and taura-beta-muricholic acid, which further strengthened the importance of FXR in mediating the anti-obesity effect.

According, to researchers, there are indications that FXR plays the similar role in Human obesity and diabetes.

I think, it's a really good breakthrough in the field of medicine, simply by alternating intestinal bacteria and getting such kind of a chain reaction which can help controlling two most common conditions as obesity and diabetes, is just awesome.

So thumbs up for a research like this, as there are about 100 trillion microbes in human body which are connected with human metabolism and health, and may provide other pathways in treating various medical conditions.

Source:

Penn State

http://www.breakthroughdigest.com/

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